Does Ivabradine SIGNIFY Improvements in Quality of Life?
نویسندگان
چکیده
منابع مشابه
Addressing Major Unmet Needs in Patients with Systolic Heart Failure: The Role of Ivabradine
We reviewed clinical evidence for the use of ivabradine in systolic heart failure (HF), in which it appears to improve symptoms, improve quality of life, prevent hospitalization, and prolong survival, thereby addressing unmet needs in the management of HF. Ivabradine provides symptomatic benefits in HF on top of standard therapies, in terms of functional parameters and exercise capacity, and th...
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INTRODUCTION The anti-anginal efficacy of ivabradine is well established. We describe a post hoc analysis in the ADDITIONS database to investigate effectiveness and tolerability of ivabradine in combination with beta-blocker in patients with angina who have had a percutaneous coronary intervention (PCI). METHODS ADDITIONS was a non-interventional, multicenter prospective study including 2,330...
متن کاملRisk-benefit assessment of ivabradine in the treatment of chronic heart failure
Heart rate is not only a major risk marker in heart failure but also a general risk marker. Within the last few years, it has been demonstrated that reduction of resting heart rate to <70 bpm is of significant benefit for patients with heart failure, especially those with impaired left ventricular systolic function. Ivabradine is the first innovative drug synthesized to reduce heart rate. It se...
متن کاملBradycardia and atrial fibrillation in patients with stable coronary artery disease treated with ivabradine: an analysis from the SIGNIFY study.
AIM The aim of this study was to determine the impact of emergent bradycardia and atrial fibrillation (AF) on cardiovascular outcomes in 19 083 patients with stable coronary artery disease (CAD) receiving ivabradine or placebo (SIGNIFY, Study assessInG the morbidity-mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease). METHODS AND RESULTS Emergent bradyc...
متن کاملIvabradine in stable coronary artery disease without clinical heart failure.
BACKGROUND An elevated heart rate is an established marker of cardiovascular risk. Previous analyses have suggested that ivabradine, a heart-rate-reducing agent, may improve outcomes in patients with stable coronary artery disease, left ventricular dysfunction, and a heart rate of 70 beats per minute or more. METHODS We conducted a randomized, double-blind, placebo-controlled trial of ivabrad...
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ورودعنوان ژورنال:
- Circulation. Cardiovascular quality and outcomes
دوره 9 1 شماره
صفحات -
تاریخ انتشار 2016